Washington, D.C.: US Government Printing Office. Guidelines for Education and Training . BLS (Bureau of Labor Statistics) U.S. Department of Labor. AAALAC relies on Three Primary Standards for evaluating laboratory animal care and use programs: the eighth edition of the Guide for the Care and Use of Laboratory Animals (Guide, NRC 2011); the Guide for the Care and Use of Agricultural Animals in Research and Teaching (Ag Guide*), American Dairy Science Association , the American Society of Animal Science, and the . 62-76 in Guide to the Care and Use of Experimental Animals, Vol. (@kanichen_hamster_wellis) bei TikTok | 1.5K Likes. 2. Female Syrian Gold hamsters were exposed either orally (100 l) or by intraperitoneal injection (50 l) to an inoculum of 263K scrapie-positive brain homogenates at the Canadian Food Inspection Agency (CFIA) Transmissible Spongiform Encephalopathy (TSE) Laboratory in Nepean, Ontario, Canada. Hamsters In Trial 1, 29 pathogen-free golden Syrian hamster (Mesocricetus auratus) weanlings (Strain 049, VAF Hamsters; Charles River Canada, Pointe Claire, Quebec) were born at the Animal . Canadian Council on Animal Care (CCAC) proceedings. Hamster procedures were performed under 5% isoflurane anesthesia. PROCEDURES 5.1. 1993. Preparation of hamster brain homogenates. rat, hamster, gerbil, guinea-pig, ferret and mink. International guidelines 6 recommend to perform the experiments with microbiological and genetically . Refining severe disease models and procedures, Stockholm, 24-25 August 2022. The use of . Assessing pain in animals, which is similar to assessing pain in human babies, relies on the observations of care staff and owners. Danke fr so viele likes und Follower Ihr seid die besten Recordkeeping Guidelines for Occupational Injuries and Illness. By Joachim Hammer . Assessments of institutional animal ethics and care programs are based on CCAC guidelines (animal care; types of animals; procedures; and program management) and assessment policies, as . Home Office Licensing overview; Establishment Licence An immigration officer with a completed Form I-485, Application to Register Permanent Residence or Adjust Status. Necropsy is the ultimate diagnostic destiny of most of the experimental animals. 1.1K Fans. Mammalian testis undergoes deep changes in their architecture and function during photoregression conditions in seasonal breeders. CCAC Guidelines: Animal Welfare Assessment ( PDF | 1,501 KB ) Canadian Council on Animal Care These 2021 guidelines discuss why we assess animal welfare, idenify welfare indicators, and explain how to record welfare assessments. Animals were housed and maintained according to the AAALAC International Guide for the Care and Use of Laboratory Animals and CCAC Guidelines for Care and Use of Experimental Animals. In the published literature, acetaminophen has been reported to be clastogenic when administered at 1500 mg/kg/day to the rat model (3.6-times the MHDD, based on a . CCAC guidelines on: The care and use of farm animals in research, teaching and testing; CCAC guidelines on: Transgenic animals (1997) . Part 1, Mouse and Rat, 418 pp. CCAC Guidelines recommend that observations should be made at least 3 times weekly for a period of 4 weeks following immunization, or until all lesions have healed. This drug and route are recommended over inhalant anesthetics, carbon dioxide, and physical methods for ethical and aesthetic reasons as well as efficiency. During this time, payment processing will not be available. The voltage-gated sodium channel Na V 1.6 is the most abundantly expressed sodium channel isoform in the central nervous system. These typically involve unusually low activity or unresponsiveness and/or reduced interest in pleasure (anhedonia). Care and welfare of the zebrafish, webinar (Lars Brutigam), 19 August 2022. Guide to the Care and use of Experimental Animals, Volume 1, 2nd Ed. However, one of the notable drawbacks in both humans and animals is observer variability (in animal studies, e.g., Beynen et al. View Record in Scopus Google Scholar. (1998) Canadian Council on Animal Care, Canada; . National Academy Press, Washington, DC 154p. Ottawa, Ontario: Canadian Council on Animal Care. Due to its unique cheek pouches, the hamster can also be used in tumor and toxicology studies. Canada's oversight of animal use in science has evolved in a different manner than many other countries. Dr. Ronald Charbonneau, Centre Hospitalier de l'Universit Laval Dr. Lee Niel, University of Toronto Dr. Ernest Olfert, University of Saskatchewan Traditionally, female animals are used for PAb production inasmuch as these animals can be group housed more successfully than males because females are more docile and less aggressive in social interaction ( Hendriksen and Hau 2003).There are, however, no overriding scientific reasons for not using male animals for PAb . The It plays a critical role in saltatory and continuous conduction. Due to the ability of Syrian golden hamsters (Mesocricetus auratus; hereafter referred to as hamsters) to satisfy many of the conditions outlined by the CCAC and the FDA, they have been used as an alternative to mice in many disease models. August 2022. Volume 1&2, 5th . The species of hamster . Species, strain and age differences often overshadow this general principle however. Guidelines for humane education: Alternatives to the use of animals in . In these cases, an Evidence of Part 2 Training to Meet CCAC Guidelines form should be submitted to the Research . CCAC proceedings. "Meri, I can't do marriage with Kody anymore," an emotional . The 2020 Edition is available for download at https://www.avma.org/KB/Policies/Documents/euthanasia.pdf . INTRODUCTION 3.1. 3. Particularly, the testicular mechanisms that regulate the transition between the active (functional) and inactive (regression) stage vary between species. 2013. The Guidelines set criteria for euthanasia, spec-ify appropriate euthanasia methods and agents, and are intended to assist veterinarians in their exercise of professional judgment. The number for each is the shortcut key. 5. Surgical Class and Analgesia Guidelines and Rodent Anesthesia and Analgesia Formulary and General Drug Information). Canadian Council on Animal Care, 1993 ISBN: -919087-18-3 Citing certain devices or manufacturers is not to be perceived as the endorsement of the Canadian Council on Animal Care (CCAC) of one particular product over another. In keeping with the CCAC policy of revising statements and guidelines as The aim of the present study was to analyze the incidence of proliferation, apoptosis and autophagy in the . Guidelines. What Fruits Can Hamsters Eat. (CCAC) guidelines, AUP number 20200016 by the University Animal Care Committee (UACC) Animal Research Ethics Board at the University . Ottawa, Ontario, Canada: CCAC. (i) Infectious prion brain homogenates (IBH). . Laboratory Animals (1998) Vol.32 p.364-368; Sisson and Grossman's "The anatomy of the domestic animals". . Pp. Skip to Content Accessible Navigation and Information. The Guidelines acknowl-edge that euthanasia is a process involving more Give the completed affidavit of support with all required documentation to the sponsored immigrant to file with either: A consular officer with a completed Form OF-230, Application for Immigrant Visa and Alien Registration; or. Reference Resources. Dr. Rene Schott presented a live, interactive webinar on reptile wildlife euthanasia techniques. Braden GC, Brice AK, Hankenson FC. Hamster food is often called hamster mix, and it usually contains seeds, nuts, dried fruits, lentils, beans, peas, and sometimes bread. This document, the CCAC guidelines on: antibody production, has been developed by the ad hoc subcommittee on immunological procedures of the Canadian Council on Animal Care (CCAC) Guidelines Committee . Inactive ingredients in the tablet and the tablet's film coating are: colloidal silicon dioxide, hypromellose Type 2910/ 3cP, 6cP, and 50cP, polyethylene glycol, microcrystalline cellulose, stearic acid, polydextrose, titanium dioxide, triacetate and triacetin. The guidelines are based on expert peer advice and current interpretation of scientific evidence. Polyclonal Antibody Production. The CCAC guidelines on: laboratory animal facilities . Taken together, we have defined the hamster model of immunopathogenesis in the context of COVID-19 which can be used to identify correlates of protection and disease, for evaluation of medical countermeasures. 17th CDC International Symposium on Biosafety, Atlanta, 27-31 August 2022. 178-192. This chapter provides guidance on the control of stress and distress in laboratory animals pharmacologicallypresenting information on the clinical uses, effects, and dosages of four groups of drugs (see Tables 6-1 and 6-2)and nonpharmacologically.. Distress in laboratory animals is usually unnecessary and unwanted. FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units; CCAC Guidelines on the Care and Use of Fish in Research, Teaching, and Testing. RESPONSIBILITY Principal Investigators (PI) and their staff, veterinary care staff , Facility Animal Care Committee (FACC) . Canadian Council on Animal Care. 4.1. Ottawa, CCAC. Mouse, Rat, Hamster, Gerbil, Guinea Pig IP/IV injection of barbiturate or anesthetic overdose Overdose of inhalant anesthetics (for species that do not breath hold), followed by a secondary method to ensure death . Occupational Health and Safety in the Care and Use of Research Animals. These may include: headache, visual disturbance, lacrimation, sweating, respiratory . (i) Infectious prion brain homogenates (IBH). Canadian Council on Animal Care. 1986. 1. The animal care and use committee at each performing laboratory approved study protocols. 2008. Oral route (gavage): 5.1.1. In general, smaller animals have higher metabolic rates and frequently require higher doses of anesthetics and analgesics at more frequent intervals to achieve the desired effect. PURPOSE This Standard Operating Procedure (SOP) describes recommended volumes and frequency for blood collection for commonly used laboratory animal species. For Gas (Isoflurane) Anesthesia - 5.1-5.13 plus: 5.14.1. Hamsters . Immigrant Visa. 2015. Ad Hoc Committee on Education of the Canadian Council on Animal Care (CCAC). 1998) as well as the interpretation of observations in terms of whether an animal is distressed. Use the following links to quickly navigate around the page. About 35% of the hamsters were used in painful procedures in 2019, with 20% being used in painful procedures for which pain-relieving drugs were not administered. Canadian Council on Animal Care, Ottawa, Ontario; 1984, 46 . Approaches to the Design and Development of Cost-Effective Laboratory Facilities. On January 15, 2020, the American Veterinary Medical Association (AVMA) issued and posted an updated version of the Guidelines for the Euthanasia of Animals. D. Neil, D. McKay. . An immunization clinical incidence form which includes the agent, route, site or sites, volume, date of injection and the body weight of the animal on the injection date may be . Abstract Describing certain animal behaviours as 'depression-like' or 'depressive' has become common across several fields of research. Cultivation of recombinant baby hamster kidney cells in a fluidized bed bioreactor system with porous borosilicate glass. While the term 'depression-like' carefully avoids directly claiming that animals are depressed, this narrative review asks whether . The Canadian Council on Animal Care (CCAC) has based its work on the Three Rs, especially since the establishment of its fundamental CCAC Policy Statement on the Ethics of Animal Investigation (1989). view of the Guidelines and are addressed by separate documents. Aquatic Facilities. 1997. As a result in 1968 the Canadian Council on Animal Care (CCAC) was formed with the support of universities and government departments involved in animal-based science. It can be difficult, however, to apply mammalian methods of euthanasia to species with . 2. . however, the 2019 ccac guideline on mice acknowledges that "there is currently a substantial amount of research being conducted in the area of inhalant techniques for euthanasia and it is important to evaluate any new evidence that becomes available." 23 the avma guidelines recommends that animals be euthanized in their home cages, when possible, Handling and care of mouse, rat, guinea pig, hamster, Peking duck, cat and dog plus specialized technique/procedure training: Email HSLAS (hslasadm@ualberta.ca) for training forms and registration details. Necropsy is the systematic dissection of an animal after death, to establish the cause of disease by macroscopic . 3. General - Pilocarpine toxicity is characterized by an exaggeration of its parasympathomimetic effects. Mutagenesis Codeine sulfate was not mutagenic in the in vitro bacterial reverse mutation assay or clastogenic in the in vitro Chinese hamster ovary cell chromosome aberration assay. CCAC guidelines establish the basic requirements for each institutional program within the Canadian system of oversight of animal ethics and care. Some seek a degree while others want to upgrade employment skills or simply take courses for personal enjoyment. CCAC guidelines on "Choosing an appropriate endpoint in experiments using animals for research, teaching and testing". CCAC guidelines are intended to provide assistance in the implementation of Russell and Burch's Three Rs (Replacement, Reduction and Refinement) principles for animals in science (Russell and Burch, 1959). ILAR, CLS, NRC. Maintenance is expected to be completed Saturday June 04, 2022 10:00 PM EDT, but may be extended beyond this time. Chapter VIII Occupational Health and Safety. In either case, the hamster will have to be grasped in the same way, at the base of the neck and then the skin adjacent to the eye must be tightened by traction with the free index finger; this will keep the eye open and make it bulge slightly. ReThink3R 2.0 Summer School, Berlin, 23-26 August 2022. 273 pp. Canadian Council on Animal Care (CCAC) guidelines (www.ccac.ca) Recommendations Use the manufacturer's recommended route of injection since some drugs may have adverse side effects or cause discomfort if injected via a nonrecommended route. 2005. 1993. By Joachim Hammer . 5.14. National Research Council. 5.13. Thank you for your understanding and support. CDC (Centers for . Hem A, Hansen AK, Rehbinder C, Voipio HM, Engh E. Scand J . Read "10.1016/j.neurobiolaging.2003.11.007" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Isoflurane 5.14.2. 1987; Holton et al. Bacterial reverse mutation assay Canadian . Guidelines for Ethical Conduct in the Care and Use of Animals. Preparation of hamster brain homogenates. CCAC Guidelines on: euthanasia of animals used in science (2010). ; Part 2, Hamster, Guinea Pig, Rabbit, and Chicken, 319 pp., Federation of American Societies for Experimental Biology, Bethesda, MD. There are many advantages to using hamsters as a disease model. 1980. Restrictions and Prohibitions on the Access, Collection and Use of Client Information . In the present study, we characterized a Na V 1.6 mutation (R1617Q . Use of Tangential Flow Filtration in Perfusion Propagation of Hybridoma Cells for Production of Monoclonal Antibodies Daniel Velez* New Brunswick Scientific Company, Incorporated, Edison, New Jersey 088 17 Llonas Miller and James D. Macmillant Department of Biochemistry and Microbiology, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick, New Jersey 08903 Accepted . Whatever your reason for choosing CCAC you can find everything you need to know about the college in the catalog. The Development of Science-based Guidelines for Laboratory Animal Care: Proceedings of the November 2003 International Workshop (2004) Animal Care and Management at the National Zoo: Interim Report (2004) National Need and Priorities for Veterinarians in Biomedical Research (2004) Guidelines for the Care and Use of Mammals in Neuroscience and The hamster can be ideal as a model for infectious diseases due to its similar immune responses to humans. This document, the CCAC guidelines on: antibody production, has been developed by the ad hoc subcommittee on immunological procedures of the Canadian Council on Animal Care (CCAC) Guidelines Committee . On Saturday June 04, 2022 from 6:00 PM EDT until 10:00 PM EDT, CEAC is scheduled for maintenance. rat, hamster, guinea pig, gerbil and rabbit experimental units. Experiments were performed in compliance with the Canadian Council on Animal Care guidelines and approved by the Animal Care Ethics Committee at the Universit Laval (protocol # 2016096-1). It is always best to start with a drug regimen . The Syrian or golden hamster, Mesocricetus auratus, is the most commonly used hamster in biomedical research. All the studies described were approved by the Animal Research Ethics Board of the University of Saskatchewan and conducted according to CCAC guidelines. FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group. Students come to CCAC for a variety of reasons and at various times in their life. Although the "3Rs" tenet (replacement, reduction, and refinement) of the Canadian Council for Animal Care (CCAC) is meant to responsibly control the use of animals in research rather than reduce experimental costs, animal models are advocated when in-vitro models have great limitations, as in the case of L. intracellularis ( 26, 27 ). rat, hamster, guinea pig and rabbit colonies in breeding and experimental units. . This document, the CCAC guidelines on: antibody production, has been developed by the ad hoc subcommittee on immunological procedures of the Canadian Council on Animal Care (CCAC) Guidelines Committee 2000 Barry Ziola Terry Pearson Mavanur Suresh Full PDF Package This Paper A short summary of this paper 37 Full PDFs related to this paper Read Paper Study details 2.3.1. . Main Office: 5205 Chairman's Court, Suite 300 Frederick, MD USA 21703 USA t: 301.696.9626 f:301.696.9627 accredit@aaalac.org The use of animals in research, teachingand testing is a privilege governed by public concerns, federal and provincial laws and regulations, the Canadian Council on Animal Care (CCAC) guidelines and policies, and McGill University policies, procedures and guidelines. In addition to the species, the sex of the animals must also be decided. Cultivation of recombinant baby hamster kidney cells in a fluidized bed bioreactor system with porous borosilicate glass. INTRODUCTION 3.1. R. A. Hoffman, P. F. Robinson, and H. Magalhaes . Phone: 780.492.3040. . Wildlife often present to veterinarians and wildlife rehabilitators with conditions that warrant euthanasia. This site . This chapter provides guidance on the control of stress and distress in laboratory animals pharmacologicallypresenting information on the clinical uses, effects, and dosages of four groups of drugs (see Tables 6-1 and 6-2)and nonpharmacologically.. Distress in laboratory animals is usually unnecessary and unwanted. Investigators are asked to consider using commercial vendors as a source of . 3. Each 5 mg pilocarpine hydrochloride tablet, USP for oral administration contains 5 mg of pilocarpine hydrochloride, USP. University Biomedical Services (UBS) Home; Home Office Licensing. Diggs HE, Parker JM. RESPONSIBILITY Principal Investigators (PI) and their staff, veterinary care staff, Facility Animal Care Committee (FACC). If administering the recommended volume, ithdrawal of food prior to oral gavage is not required.w If using 1. This document, the CCAC guidelines on: euthanasia of animals used in science, has been developed by the ad hoc subcommittee on euthanasia of the Canadian Council on Animal Care (CCAC) Guidelines Committee. Blood samples (90-180 l) were collected from each hamster at 6, 24, 48, 72, 96, 120, 144, and 168 h post-treatment via the saphenous vein and serum was tested for the presence of alpaca . In this article, we review laws and guidelines relating to rodent enrichment, and discuss the natural behaviors of select rodent species in an effort to define activities that would mimic innate patterns of behavior, thus potentially reducing stress in captive rodents. Though she has her own issues with Kody, Meri still finds herself comforting Christine, who questions if she wants to remain married. . Adverse effects of vapocoolant and topical anesthesia for tail biopsy of preweanling mice. Hamsters usually enjoy the following fruits: apples, bananas (ripe), blueberries, blackberries, cantaloupe (ripe), cucumber slices, or chunks of cucumber and dill pickles. Welfare Assessment National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs). ADVERSE REACTIONS Head & Neck Cancer Patients - In controlled studies, 217 patients received pilocarpine, of whom 68% were men and 32% were women. (CCAC) + Guidelines for lab, farm, fish and wildlife research www.ccac.ca . Arising from a study in 1966, the Canadian Council on Animal Care (CCAC) was established as a peer review system heavily reliant on the contribution of volunteer experts to contribute to the development of standards and the assurance of compliance both within institutions and nationally . The Canadian Council on Animal Care (CCAC 1) . nonhuman primate, guinea pig, hamster, rabbit, or any other warm-blooded animal, which is being used, or is intended for use for research, teaching, testing, experimentation . Abstract. The Golden Hamster: Its Biology and Use in Medical Research. Although over 40 Na V 1.6 mutations have been linked to epileptic encephalopathy, only a few have been functionally analysed. 2.3. PURPOSE This Standard Operating Procedure (SOP) describes recommended volumes and frequency for blood collection for commonly used laboratory animal species. Cage flags, procedure log and/or monitoring sheets (see Policy # 17 Monitoring of Animals Used for Research, Teaching and Testing). UCLA investigators are encouraged to use the information outlined below in designing the most efficient immunization protocols in terms of the efficacy of antibody production and minimizing potential pain and distress to the animals used. 1. View the RACE-approved webinar recording today. The hamster handling protocol used in this study adhered to the Canadian Council of Animal Care (CCAC, Canada) guidelines. 1995. Syrian (golden) hamsters are the most commonly used species, although English (black) and Chinese hamsters are used in research protocols as well. hamster, gerbil, guinea-pig, ferret and mink Visibility! Species-Specific Considerations. 11. In accessing Client Information via Health Partner Gateway, I shall comply with applicable privacy laws, including the Personal Health Information Protection Act, 2004 (PHIPA), professional standards and guidelines and organizational policies and procedures. Lab Anim 47:134-145. Lab Anim, 48 (2014), pp. Not necessarily in a high-impact journal. . The use of sodium pentobarbital, injected intraperitoneally, for killing rodents is described as an acceptable technique by the AVMA and CCAC euthanasia guidelines. All work was conducted in accordance with the Canadian Council of Animal Care (CCAC) guidelines, AUP number 20200016 by the University Animal Care Committee (UACC) Animal Research Ethics Board at the University of Saskatchewan. All are valid reasons for attending CCAC.